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Carvedilol taken with calcium channel blockers ccbs such as diltiazem cardizem or verapamil calan may trigger an irregular heart rhythm or an increase in blood pressure.

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azithromycin moderate both diltiazem and azithromycin are p-glycoprotein p-gp inhibitors and substrates, so coadministration may lead to increased concentrations of either agent.

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isolated cases of conduction disturbance rarely with hemodynamic compromise have been observed when carvedilol is co-administered with diltiazem.

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in one parallel-group study of 198 patients diltiazem hydrochloride extended-release capsules were given for four weeks.

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